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292 articles · Updated daily
🧬 Hydroxychloroquine

Hydroxychloroquine: One Drug, Two Mechanisms Explained

Hydroxychloroquine fights malaria and calms lupus through the same basic trick: making acidic cellular compartments less acidic.

mechanismautoimmune disease
✍️ Dr. James Harmon, Research Correspondent · 2026-09-17 Read →
🩺 Doxycycline

Doxycycline for Cat-Scratch Disease and Bartonella Infections

Doxycycline is the preferred antibiotic for serious Bartonella infections, though most cat-scratch disease resolves without any drug at all.

conditionmechanism
✍️ Dr. James Harmon, Research Correspondent · 2026-09-17 Read →
💉 Azithromycin

The Morges Strategy: Azithromycin and the Fight to End Yaws

A single oral dose of azithromycin is replacing painful penicillin shots in the global campaign against yaws. Here is what the evidence actually shows.

drug historypublic healthcondition
✍️ Dr. James Harmon, Research Correspondent · 2026-09-17 Read →
⚗️ Mebendazole

Mebendazole's 2011 Reformulation and Its Effect on Absorption

In 2011 mebendazole moved from chewable to film-coated tablets. Here is what changed pharmacologically, and what the evidence actually shows about treatment failures.

drug historydosingformulation
✍️ Dr. James Harmon, Research Correspondent · 2026-09-17 Read →
🩺 Doxycycline

Subantimicrobial Doxycycline: Anti-Inflammatory, Not Antibiotic

Low-dose doxycycline treats rosacea and gum disease through an anti-inflammatory pathway distinct from its antibiotic action—a genuine pharmacological discovery worth understanding.

rosaceadosingmechanism
✍️ Dr. James Harmon, Research Correspondent · 2026-09-16 Read →
🩺 Doxycycline

Doxycycline for Malaria Prevention: Timing and Why Doses Matter

Doxycycline prevents malaria by stopping the parasite before it can multiply—but only if taken on schedule. Here is the biology behind the regimen and the timing rules.

malaria prophylaxistravel medicineadherence
✍️ Dr. James Harmon, Research Correspondent · 2026-09-16 Read →
💊 Ivermectin

Ivermectin Lotion for Head Lice: Ovicidal vs. Pediculicidal Action

Topical ivermectin kills lice but not their eggs—yet clinical trials show it still breaks the infestation cycle. Here's the evidence and how it compares with permethrin.

head licemechanismtopical
✍️ Dr. James Harmon, Research Correspondent · 2026-09-16 Read →
💊 Ivermectin

Oral Ivermectin for Crusted Scabies: Why Dosing Differs

Crusted (Norwegian) scabies in immunocompromised patients needs several ivermectin doses over weeks, not one. Here is the biology and evidence behind why.

scabiesimmunocompromiseddosing
✍️ Dr. James Harmon, Research Correspondent · 2026-09-16 Read →
🧬 Hydroxychloroquine

Chloroquine to Hydroxychloroquine: A History of Resistance

How a bark-derived remedy from the Andes led to two related drugs, and why parasite resistance—not hydroxychloroquine—became malaria's real challenge.

drug historymalariaresistance
✍️ Dr. James Harmon, Research Correspondent · 2026-09-16 Read →