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292 articles · Updated daily
💊 Ivermectin

Ivermectin's Origins: From Japanese Soil to the 2015 Nobel Prize

A single soil microbe from Japan yielded a family of compounds that reshaped veterinary medicine and the fight against river blindness. This is the history of ivermectin, told carefully and accurately.

drug historyonchocerciasisnobel prize
✍️ Dr. James Harmon, Research Correspondent · 2026-10-12 Read →
🔭 Praziquantel

Praziquantel for Tapeworm Carriers: Seizure Risk and Screening

Praziquantel cures pork tapeworm but can provoke seizures if brain cysts are present and undetected. Here is why that happens and how careful clinicians screen first.

taeniasisneurocysticercosissafety
✍️ Dr. James Harmon, Research Correspondent · 2026-10-12 Read →
⚗️ Mebendazole

Mebendazole for Toddlers: Dosing at 12–23 Months and Chewable Tablets

WHO halves the albendazole dose for children aged 12–23 months but keeps mebendazole at 500 mg. Here is why, and how a chewable tablet lowers choking risk for toddlers.

pediatricsdosing principlewho guidance
✍️ Dr. James Harmon, Research Correspondent · 2026-10-05 Read →
💉 Azithromycin

Why Azithromycin Keeps Working After the Last Pill

A short azithromycin course works because the drug builds up inside cells and tissues and leaves slowly. Here is what the research shows, and what it means for patients.

pharmacokineticsdosing principlehalf-life
✍️ Dr. James Harmon, Research Correspondent · 2026-10-05 Read →
🔬 Fenbendazole

How Fenbendazole Kills Parasites: Beta-Tubulin and Oxfendazole

Fenbendazole and its relatives starve parasites by disabling a single protein, beta-tubulin. Here is how that binding works, why it largely spares the host, and what the body turns fenbendazole into.

mechanismpharmacologyveterinary medicine
✍️ Dr. James Harmon, Research Correspondent · 2026-10-05 Read →
🧬 Hydroxychloroquine

Hydroxychloroquine in Lupus Pregnancy: Flares, Safety and Heart Block

For pregnant women with lupus, continuing hydroxychloroquine lowers flare risk and appears safe for the baby. It may also reduce the risk of congenital heart block in anti-Ro-positive mothers.

pregnancylupussafety
✍️ Dr. James Harmon, Research Correspondent · 2026-10-05 Read →
💊 Ivermectin

Loa Loa, Ivermectin and Encephalopathy: Why Test-and-Not-Treat Works

People heavily infected with Loa loa can suffer brain injury after ivermectin. Measuring microfilarial density first, and deferring the few at risk, has made river blindness treatment safer.

safetyloiasisonchocerciasis
✍️ Dr. James Harmon, Research Correspondent · 2026-10-05 Read →
🌿 Albendazole

Albendazole Plus Praziquantel for Neurocysticercosis: The Trial Evidence

A randomized trial in Peru found that adding praziquantel to albendazole cleared all brain cysts in more patients with multiple viable cysts. Here is what it showed and what it did not.

neurocysticercosiscombination therapyclinical trials
✍️ Dr. James Harmon, Research Correspondent · 2026-09-28 Read →
🔭 Praziquantel

How Praziquantel Paralyzes Schistosomes: The TRPM Channel Explained

For 40 years no one knew exactly how praziquantel kills blood flukes. Research published in 2021 identified a worm calcium channel as its target, explaining paralysis and skin damage.

mechanismschistosomiasispharmacology
✍️ Dr. James Harmon, Research Correspondent · 2026-09-28 Read →