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Praziquantel Articles
24 articles · Updated daily
🔭 Praziquantel

Rifampin and Praziquantel: Why the Dewormer Can Fail During TB Treatment

Rifampin speeds up the liver enzymes that clear praziquantel, sometimes leaving blood levels too low to measure. Here is the evidence, and how clinicians handle the clash.

drug interactionspharmacokineticsmetabolism
✍️ Dr. James Harmon, Research Correspondent · 2026-11-02 Read →
🔭 Praziquantel

Why Praziquantel Misses Young Schistosomes, and Why Doctors Retreat

Praziquantel kills adult blood flukes well but largely spares the juvenile worms present in early infection. This explains Katayama fever's timing and why repeat treatment at 6 to 12 weeks is standard.

schistosomiasisparasite life cycletravel medicine
✍️ Dr. James Harmon, Research Correspondent · 2026-10-12 Read →
🔭 Praziquantel

Praziquantel for Tapeworm Carriers: Seizure Risk and Screening

Praziquantel cures pork tapeworm but can provoke seizures if brain cysts are present and undetected. Here is why that happens and how careful clinicians screen first.

taeniasisneurocysticercosissafety
✍️ Dr. James Harmon, Research Correspondent · 2026-10-12 Read →
🔭 Praziquantel

How Praziquantel Paralyzes Schistosomes: The TRPM Channel Explained

For 40 years no one knew exactly how praziquantel kills blood flukes. Research published in 2021 identified a worm calcium channel as its target, explaining paralysis and skin damage.

mechanismschistosomiasispharmacology
✍️ Dr. James Harmon, Research Correspondent · 2026-09-28 Read →
🔭 Praziquantel

Praziquantel and Fatty Meals: The Science Behind Dosing Rules

A fatty meal can markedly change how much praziquantel reaches the bloodstream. Here is the pharmacology behind that effect and how dosing guidance accounts for it.

dosingpharmacokineticsfood interaction
✍️ Dr. James Harmon, Research Correspondent · 2026-09-22 Read →
🔭 Praziquantel

Praziquantel's Bitter Taste Problem and the Fix for Children

Praziquantel cures schistosomiasis but tastes so bitter that young children spit it out or vomit it up—new research aims to finally fix that.

praziquantelformulationpediatric dosing
✍️ Dr. James Harmon, Research Correspondent · 2026-09-19 Read →
🔭 Praziquantel

Praziquantel Cure Rates: S. mansoni vs Haematobium vs Japonicum

Praziquantel cures schistosomiasis reliably, but not equally. The parasite species, the worm's age, and even the patient's own immune system all shape the outcome.

schistosomiasismechanismdosing
✍️ Dr. James Harmon, Research Correspondent · 2026-09-18 Read →
🔭 Praziquantel

Praziquantel's Calcium Influx Mechanism in Schistosomiasis

Praziquantel kills schistosome blood flukes by forcing calcium into their muscle cells, causing paralysis and exposing them to immune attack—a mechanism decades in the unraveling.

praziquantelparasitesmechanism
✍️ Dr. James Harmon, Research Correspondent · 2026-09-05 Read →
🔭 Praziquantel

Praziquantel for Tapeworm: Evidence, Dosing, What to Expect

Praziquantel is the treatment of choice for most intestinal tapeworm infections, typically cured with a single well-studied dose.

praziquantelconditiontapeworm
✍️ Dr. James Harmon, Research Correspondent · 2026-09-01 Read →